Release 3.1 (May 2023): 11,000 critical Covid cases

Update of release 3. Analysis of 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). These were combined with unpublished results from 23andMe and published data from the HGIv6 meta-analysis. We find an additional 16 new genetic associations including potentially druggable targets in inflammatory signalling (JAK1, PDE4A), monocyte-macrophage differentiation (CSF2), immunometabolism (SLC2A5, AK5), and host factors required for viral entry and replication (TMPRSS2, RAB2A).

Results

Bulk Summary Statistics Download:

Summary statistics for ancestry specific analyses and trans-ancestry meta analysis for GenOMICC only cases:

• GenOMICC_AFR.tsv.gz (93.23Mb)
• GenOMICC_EAS.tsv.gz (71.80Mb)
• GenOMICC_EUR.tsv.gz (138.0Mb)
• GenOMICC_SAS.tsv.gz (108.5Mb)
• GenOMICC_TE_meta.tsv.gz (278.1Mb)

Meta analysis of GenOMICC, SCOURGE and HGIv6:

• GenOMICC_international_meta_release3_critical.tsv.gz (223.5Mb)
• GenOMICC_international_meta_release3_hospitalised.tsv.gz (196.9Mb)

Bulk Summary Statistics Downloads for r3:

Previously published summary statistics which were used in the pre-print version of the final paper can be be downloaded here (password = covid)